2024

Oncostatin M receptor-dependent signaling assessed by RNA sequencing in mouse hematopoietic stem cells. Sci Data. 2024 Aug 28. accepted for publication

Metformin reduces the clonal fitness of Dnmt3aR878H hematopoietic stem and progenitor cells by reversing their aberrant metabolic and epigenetic state. Res Sq. 2024 Feb 6. doi:10.21203/rs.3.rs-3874821/v1. Preprint

Mesenchymal stromal cell senescence induced by Dnmt3a-mutant hematopoietic cells is a targetable mechanism driving clonal hematopoiesis and initiation of hematologic malignancy. bioRxiv. 2024 Mar 30. doi:10.1101/2024.03.28.587254. Preprint

Variation in mesenchymal KITL/SCF and IGF1 expression at middle age underlies steady-state hematopoietic stem cell aging. Young KA, Telpoukhovskaia MA, Hofmann J, Mistry JJ, Kokkaliaris K, Trowbridge JJ. Blood. 2024 Jul 25; 144(4):378-391. doi:10.1182/blood.2024024275. Featured on cover.

Transcriptional and functional consequences of Oncostatin M signaling on young Dnmt3a-mutant hematopoietic stem cells. Schwartz LS, Young KA, Stearns TM, Boyer N, Mujica KD, Trowbridge JJ. Exp Hematol. 2024 Feb; 130:104131. doi:10.1016/j.exphem.2023.11.005.

2023

Characterization of an Osmr conditional knockout mouse model. Schwartz LS, Saxl RS, Stearns T, Trowbridge JJ. bioRxiv. 2023 Nov 1. doi:10.1101/2023.10.27.564474. Preprint

New insight into the causes, consequences and correction of hematopoietic stem cell aging. Mansell E, Lin DS, Loughran SJ, Milsom MD, Trowbridge JJ. Experimental Hematology. 2023 Jul 9. doi: 10.1016/j.exphem.2023.07.002. Online ahead of print.

Clonal hematopoiesis, aging and Alzheimer’s disease. Sánchez Vela P, Trowbridge JJ, Levine RL. Nature Medicine. 2023 Jul 4. doi: 10.1038/s41591-023-02406-4. Online ahead of print.

Variation in histone configurations correlates with gene expression across nine inbred strains of mice. Tyler AL, Spruce C, Kursawe R, Haber A, Ball RL, Pitman WA, Fine AD, Raghupathy N, Walker M, Philip VM, Baker CL, Mahoney JM, Churchill GA, Trowbridge JJ, Stitzel ML, Paigen K, Petkov PM, Carter GW. Genome Res. 2023 May 22:gr.277467.122. Online ahead of print.

Challenges and opportunities for modeling aging and cancer. Anczuków O, Airhart S, Chuang JH, Coussens LM, Kuchel GA, Korstanje R, Li S, Lucido AL, McAllister SS, Politi K, Polyak K, Ratliff T, Ren G, Trowbridge JJ, Ucar D, Palucka K. Cancer Cell. 2023 Apr 10;41(4):641-645.

Hematopoietic Stem Cell Aging and Leukemia Transformation. Colom Díaz PA, Mistry JJ, Trowbridge JJ. Blood. 2023 Feb 17:blood.2022017933. Online ahead of print.

2022

Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness Versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis. SanMiguel JM, Eudy E, Loberg MA, Young KA, Mistry JJ, Mujica KD, Schwartz LS, Stearns TM, Challen GA, Trowbridge JJ. Cancer Discovery. 2022 Dec 2;12(12):2763-2773.

Modeling clonal evolution and oncogenic dependency in vivo in the context of hematopoietic transformation. Bowman RL, Dunbar A, Mishra T, Xiao W, Waarts MR, Fernández Maestre I, Eisman SE, Cai L, Cai SF, Sanchez Vela P, Mowla S, Martinez Benitez AR, Park Y, Csete IS, Krishnan A, Lee D, Boorady N, Potts CR, Jenkins MT, Carroll MP, Meyer SE, Miles LA, Ferrell BF, Trowbridge JJ, Levine RL. bioRxiv. 2022. https://doi.org/10.1101/2022.05.18.492524

Cell Origin-Dependent Cooperativity of Mutant Dnmt3a and Npm1 in Clonal Hematopoiesis and Myeloid Malignancy. SanMiguel JM, Eudy E, Loberg MA, Miles LA, Stearns T, Mistry JJ, Rauh MJ, Levine RL, Trowbridge JJ. Blood Advances. 2022 Jun 28;6(12):3666-3677.

2021

Actinomycin D targets NPM1C-primed mitochondria to restore PML-driven senescence in AML therapy. Wu HC, Rerolle D, Berthier C, Hleihel R, Sakamoto T, Quentin S, Benhenda S, Morganti C, Wu C, Conte L, Rimsky S, Sebert M, Clappier E, Souquere S, Gachet S, Soulier J, Durand S, Trowbridge JJ, Benit P, Rustin P, El Hajj H, Raffoux E, Ades L, Itzykson R, Dombret H, Fenaux P, Espeli O, Kroemer G, Brunetti L, Mak TW, Lallemand-Breitenbach V, Bazarbachi A, Falini B, Ito K, Martelli MP, de The H. Cancer Discovery. 2021 Dec 1;11(12):3198-3213.

Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS. Trowbridge JJ, Starczynowski DT. Journal of Experimental Medicine. 2021 July 5; 218(7):e20201544.

Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging. Young K, Eudy E, Bell R, Loberg MA, Stearns T, Sharma D, Velten L, Haas S, Filippi MD, Trowbridge JJ. Cell Stem Cell. 2021 Aug 5; 28(8):1473-1482. Preprint (bioRxiv) 10.1101/2020.07.11.198846

2020

Hand in Hand: Intrinsic and Extrinsic Drivers of Aging and Clonal Hematopoiesis. SanMiguel JM, Young K, Trowbridge JJ. Experimental Hematology. 2020 Nov; 91:1-9.

Heritable Genetic Background Alters Survival and Phenotype of Mll-AF9-Induced Leukemias. Young K, Loberg MA, Eudy E, Schwartz LS, Mujica KD, Trowbridge JJ. Experimental Hematology. 2020 July 30; 89:61-67.

The Lethal Sex Gap: COVID-19. Marquez EJ, Trowbridge J, Kuchel GA, Banchereau J, Ucar D. Immune Aging. 2020 May 21; 17:13.

Aging-Associated Decreased in the Histone Acetyltransferase KAT6B is Linked to Altered Hematopoietic Stem Cell Differentiation. Khokhar ES, Borikar S, Eudy E, Stearns T, Young K, Trowbridge JJ. Experimental Hematology. 2020 Feb; 82:43-52.

2019

Context-specific Tumor Suppression by PHF6. Trowbridge JJ. Blood. 2019 Apr 18; 133(16):1698.

Sequentially Inducible Mouse Models Reveal That Npm1 Mutation Causes Malignant Transformation of Dnmt3a-Mutant Clonal Hematopoiesis. Loberg MA, Bell RK, Goodwin LO, Eudy E, Miles LA, SanMiguel JM, Young K, Bergstrom DA, Levine RL, Schneider RK, Trowbridge JJ. Leukemia. 2019 Jul; 33(7):1635-1649.

2017

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer. Hsu JH, Hubbell-Engler B, Adelamant G, Huang J, Joyce CE, Vazquez F, Weir BA, Montgomery P, Tsherniak A, Giacomelli AO, Perry JA, Trowbridge J, Fujiwara Y, Cowley GS, Xie H, Kim W, Novina CD, Hahn WC, Marto JA, Orkin SH. Cancer Research. 2017 Sep 1; 77(17):4613.

2016

The mediator of hematopoietic stem cell homeostasis. Borikar S, Trowbridge JJ. Cell Stem Cell. 2016 Dec 1; 19(6):677.

Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging. Young K, Borikar S, Bell R, Kuffler L, Philip V, Trowbridge JJ. The Journal of Experimental Medicine. 2016 Oct 17;213(11):2259. doi: 10.1084/jem.20160168.

Open chromatin profiling as a novel strategy for identifying cancer cell-of-origin. Young K, Trowbridge JJ. Molecular & Cellular Oncology. 2016 Sep 30; Epub ahead of print doi:10.1080/23723556.2016.1236770

Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Burberry A, Suzuki N, Wang JY, Moccia R, Mordes DA, Stewart MH, Suzuki-Uematsu S, Ghosh S, Singh A, Merkle FT, Koszka K, Li QZ, Zon L, Rossi DJ, Trowbridge JJ, Notarangelo LD, Eggan K. Science Translational Medicine. 2016 Jul 13;8(347):347ra93. doi: 10.1126/scitranslmed.aaf6038.

Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells. George J, Uyar A, Young K, Kuffler L, Waldron-Francis K, Marquez E, Ucar D, Trowbridge JJ. Nature Communications. 2016 Jul 11;7:12166. doi: 10.1038/ncomms12166.

2014

Role of DNA methyltransferases and DNA methylation in cell fate decisions during blood cell development and leukemia. Challen GA, Trowbridge JJ. In C. Bonifer & P. Cockerill (Eds.), Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development. 2014 Springer Publishing.

2013

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Xu J, Bauer DE, Kerenyi MA, Vo TD, Hou S, Hsu YJ, Yao H, Trowbridge JJ, Mandel G, Orkin SH. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6518-23. doi: 10.1073/pnas.1303976110. Epub 2013 Apr 1.

TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Bai X, Trowbridge JJ, Riley E, Lee JA, DiBiase A, Kaartinen VM, Orkin SH, Zon LI. Developmental Biology. 2013 Jan 15;373(2):422-30. doi: 10.1016/j.ydbio.2012.10.008. Epub 2012 Nov 16.

2012

Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Trowbridge JJ, Sinha AU, Zhu N, Li M, Armstrong SA, Orkin SH. Genes & Development. 2012 Feb 15;26(4):344-9. doi: 10.1101/gad.184341.111.

2011

Dnmt3a silences hematopoietic stem cell self-renewal. Trowbridge JJ, Orkin SH. Nature Genetics. 2011 Dec 27;44(1):13-4. doi: 10.1038/ng.1043.

Context-dependent function of “GATA switch” sites in vivo. Snow JW, Trowbridge JJ, Johnson KD, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH. Blood. 2011 May 5;117(18):4769-72. doi: 10.1182/blood-2010-10-313031. Epub 2011 Mar 11.

Hematopoietic stem cells. Trowbridge JJ. In S. Li, N. L’Heureux, & J. Elisseeff (Eds.), Stem Cell and Tissue Engineering (pp.31-48). 2011 Singapore: World Scientific Publishing.

2010