Publications

2017

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer. Hsu JH, Hubbell-Engler B, Adelamant G, Huang J, Joyce CE, Vazquez F, Weir BA, Montgomery P, Tsherniak A, Giacomelli AO, Perry JA, Trowbridge J, Fujiwara Y, Cowley GS, Xie H, Kim W, Novina CD, Hahn WC, Marto JA, Orkin SH. Cancer Research. 2017 Sep 1; 77(17):4613.

2016

The mediator of hematopoietic stem cell homeostasis. Borikar S, Trowbridge JJ. Cell Stem Cell. 2016 Dec 1; 19(6):677.

Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging. Young K, Borikar S, Bell R, Kuffler L, Philip V, Trowbridge JJ. The Journal of Experimental Medicine. 2016 Oct 17;213(11):2259. doi: 10.1084/jem.20160168.

Open chromatin profiling as a novel strategy for identifying cancer cell-of-origin. Young K, Trowbridge JJ. Molecular & Cellular Oncology. 2016 Sep 30; Epub ahead of print doi:10.1080/23723556.2016.1236770

Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Burberry A, Suzuki N, Wang JY, Moccia R, Mordes DA, Stewart MH, Suzuki-Uematsu S, Ghosh S, Singh A, Merkle FT, Koszka K, Li QZ, Zon L, Rossi DJ, Trowbridge JJ, Notarangelo LD, Eggan K. Science Translational Medicine. 2016 Jul 13;8(347):347ra93. doi: 10.1126/scitranslmed.aaf6038.

Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells. George J, Uyar A, Young K, Kuffler L, Waldron-Francis K, Marquez E, Ucar D, Trowbridge JJ. Nature Communications. 2016 Jul 11;7:12166. doi: 10.1038/ncomms12166.

2014

Role of DNA methyltransferases and DNA methylation in cell fate decisions during blood cell development and leukemia. Challen GA, Trowbridge JJ. In C. Bonifer & P. Cockerill (Eds.), Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development. 2014 Springer Publishing.

2013

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Xu J, Bauer DE, Kerenyi MA, Vo TD, Hou S, Hsu YJ, Yao H, Trowbridge JJ, Mandel G, Orkin SH. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6518-23. doi: 10.1073/pnas.1303976110. Epub 2013 Apr 1.

TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Bai X, Trowbridge JJ, Riley E, Lee JA, DiBiase A, Kaartinen VM, Orkin SH, Zon LI. Developmental Biology. 2013 Jan 15;373(2):422-30. doi: 10.1016/j.ydbio.2012.10.008. Epub 2012 Nov 16.

2012

Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Trowbridge JJ, Sinha AU, Zhu N, Li M, Armstrong SA, Orkin SH. Genes & Development. 2012 Feb 15;26(4):344-9. doi: 10.1101/gad.184341.111.

2011

Dnmt3a silences hematopoietic stem cell self-renewal. Trowbridge JJ, Orkin SH. Nature Genetics. 2011 Dec 27;44(1):13-4. doi: 10.1038/ng.1043.

Context-dependent function of “GATA switch” sites in vivo. Snow JW, Trowbridge JJ, Johnson KD, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH. Blood. 2011 May 5;117(18):4769-72. doi: 10.1182/blood-2010-10-313031. Epub 2011 Mar 11.

Hematopoietic stem cells. Trowbridge JJ. In S. Li, N. L’Heureux, & J. Elisseeff (Eds.), Stem Cell and Tissue Engineering (pp.31-48). 2011 Singapore: World Scientific Publishing.

2010

A single cis element maintains repression of the key developmental regulator Gata2. Snow JW, Trowbridge JJ, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH. PLoS Genetics. 2010 Sep 9;6(9):e1001103. doi: 10.1371/journal.pgen.1001103.

Wnt3a activates dormant c-Kit(-) bone marrow-derived cells with short-term multilineage hematopoietic reconstitution capacity. Trowbridge JJ, Guezguez B, Moon RT, Bhatia M. Stem Cells. 2010 Aug;28(8):1379-89. doi: 10.1002/stem.457.

DNA methylation in adult stem cells: new insights into self-renewal. Trowbridge JJ, Orkin SH. Epigenetics. 2010 Apr;5(3):189-93. Epub 2010 Apr 1.

2009

DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Trowbridge JJ, Snow JW, Kim J, Orkin SH. Cell Stem Cell. 2009 Oct 2;5(4):442-9. doi: 10.1016/j.stem.2009.08.016.

2008

Proteomic studies of stem cells. Wang J, Trowbridge JJ, Rao S, Orkin SH. StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008 Jul 14.

2006

Hematopoietic stem cell biology: too much of a Wnt thing. Trowbridge JJ, Moon RT, Bhatia M. Nature Immunology. 2006 Oct;7(10):1021-3.

Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Trowbridge JJ, Scott MP, Bhatia M. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14134-9. Epub 2006 Sep 12.

Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation. Trowbridge JJ, Xenocostas A, Moon RT, Bhatia M. Nature Medicine. 2006 Jan;12(1):89-98. Epub 2005 Dec 11.

2005

A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis. Rosu-Myles M, Stewart E, Trowbridge J, Ito CY, Zandstra P, Bhatia M. Journal of Cell Science. 2005 Oct 1;118(Pt 19):4343-52. Epub 2005 Sep 6.

Hierarchical and ontogenic positions serve to define the molecular basis of human hematopoietic stem cell behavior. Shojaei F, Trowbridge J, Gallacher L, Yuefei L, Goodale D, Karanu F, Levac K, Bhatia M. Developmental Cell. 2005 May;8(5):651-63.